Research and Development

Research Program

Airway Clearance by rheology

Simeox is the result of several years of research and development in partnership with CNRS and CRCM (Resources and competences center for cystic fibrosis) Hôpital Nord in Marseille (France) 1, 2, 3.

The PhysioAssist research program was devoted to the study of bronchial mucus and helped develop the technology present in the Simeox device.

1 Lafforgue, Olivier & Bouguerra, Nizar & Poncet, Sébastien & Seyssiecq, Isabelle & Favier, Julien & Elkoun, Saïd. (2017). Thermo-physical properties of synthetic mucus for the study of airway clearance. Journal of Biomedical Materials Research Part A. 105. 3025-3033. 10.1002/jbm.a.36161.

2 Lafforgue, Olivier & Seyssiecq, Isabelle &Poncet, Sébastien & Favier, Julien. (2017). Rheological properties of synthetic mucus for airway clearance. Journal of Biomedical Materials Research Part A. . 10.1002/jbm.a.36251.

3 Lafforgue, Olivier & Poncet, Sébastien & Seyssiecq, Isabelle & Favier, Julien. (2016). Rheological Characterization of Macromolecular Colloidal Gels as Simulant of Bronchial Mucus.

Our Mission

Innovate for improving the quality of life of patients with chronic respiratory conditions

Modification of the mucus rheology allows, in pathologies that make it abundant and viscous, improvement of bronchial decongestion.

Conclusions of the simulations done by the CNRS laboratory M2P2:

During testing in a tube representing the generation 20 of the bronchial tree with the use of Simeox, a significant drop was observed in the dynamic viscosity of mucus.