Research and Development

Research Program

Airway Clearance by rheology

Simeox is the result of several years of research and development in partnership with CNRS and CRCM (Resources and competences center for cystic fibrosis) Hôpital Nord in Marseille (France) 1, 2, 3.

The PhysioAssist research program was devoted to the study of bronchial mucus and helped develop the technology present in the Simeox device.

1 Lafforgue, Olivier & Bouguerra, Nizar & Poncet, Sébastien & Seyssiecq, Isabelle & Favier, Julien & Elkoun, Saïd. (2017). Thermo-physical properties of synthetic mucus for the study of airway clearance. Journal of Biomedical Materials Research Part A. 105. 3025-3033. 10.1002/jbm.a.36161.

2 Lafforgue, Olivier & Seyssiecq, Isabelle &Poncet, Sébastien & Favier, Julien. (2017). Rheological properties of synthetic mucus for airway clearance. Journal of Biomedical Materials Research Part A. . 10.1002/jbm.a.36251.

3 Lafforgue, Olivier & Poncet, Sébastien & Seyssiecq, Isabelle & Favier, Julien. (2016). Rheological Characterization of Macromolecular Colloidal Gels as Simulant of Bronchial Mucus.

Our Mission

Innovate for improving the quality of life of patients with chronic respiratory conditions

Modification of the mucus rheology allows, in pathologies that make it abundant and viscous, improvement of bronchial decongestion.

Conclusions of the simulations done by the CNRS laboratory M2P2:

During testing in a tube representing the generation 20 of the bronchial tree with the use of Simeox, a significant drop was observed in the dynamic viscosity of mucus.

Research Committee

Sébastien Poncet

Jr engineer, PhD, HDR Associate Professor Sherbrooke University CANADA

Holder of the NSERC Research Chair in Industrial Energy Efficiency Sébastien Poncet directs research Physio-Assist since 2011 in order to develop our understanding of the rheology of mucus. This expertise enables the optimization of signal processing medical equipment Physio-Assist and generated waves on the airways in order to improve efficiency.

Isabelle Seyssiecq

Jr engineer, PhD, HDR conference Master - CNRS - Université Aix-Marseille

Isabelle Seyssiecq specializes in studying the rheology of materials and process optimization. Isabelle Seyssiecq accompanies Physio-Assist since 2011 in the development of technological expertise of the rheology of bronchial mucus. She produces in-vitro research to Physio-Assist. This knowledge allows you to be more effective in adapting our medical devices for changing the patient mucus structure.

Julien Favier

Jr engineer, PhD, HDR conference Master CNRS - Université Aix-Marseille

Julien Favier specializes in the problems of turbulence and instability. Julien Favier accompanies Physio-Assist since 2013 in the development of its medical devices by producing depth studies on the distribution of the signal in the bronchi. Mastering this knowledge now allows Simeox to reach the lower tract of patients.

Olivier Lafforgue

Engineer, PhD CIFRE PHYSIO-ASSIST - CNRS Université Aix-Marseille

Team instability, turbulence and Control the rheology of mucus study, experimental and numerical approach Mr. Lafforgue coordinates research at the CNRS and the link with Physio-Assist. Since 2014, he develops and improves models Physio-Assist to help improve treatment and expand the applications of our technology.




The support of a pioneer in the sector

Patrick Sangouard

Patrick Sangouard, professor in microelectronics and materials physics, is a pioneer in the application of the physical principle of thixotropy to the field of life.

Following the death of his two children with cystic fibrosis, Patrick Sangouard wanted to improve the quality of life for these patients thanks to his scientific expertise.

In early 1987, he was the first to think of the “thixotropy” of bronchial mucus, a physical property that allows it to liquefy under the influence of a mechanical stimulus.