Phone +33 (0)4 67 03 13 92

Simeox as a standard of care

At PhysioAssist, we are investing in basic and clinical research to establish Simeox as a standard of care in the airway clearance management of patients suffering from obstructive lung diseases. Clinical validation is essential to achieve this goal and well as to drive coverage in homecare markets.

Published studies

  • All
  • BE
  • CF
  • COPD

De Macedo J, Reychler G, Poncin W, Liistro G. Effects of the intermittent intrapulmonary deflation technique on expiratory flow limitation: an in vitro study.

J Clin Monit Comput. 2023 Nov 2. doi: 10.1007/s10877-023-01093-3. Epub ahead of print. PMID: 37917211


Hamidfar R, MurrisEspin M, Mahot M, et al. Feasibility of home initiation of an airway clearance device (SIMEOX) by telecare in people with non-cystic fibrosis bronchiectasis: a pilot study.

BMJ Open Respir Res 2023;10:e001722. doi:10.1136/ bmjresp-2023-001722


Juliana Ribeiro Fonseca Franco de Macedo, Gregory Reychler, Giuseppe Liistro and William Poncin: Short-Term Effect of Intermittent Intrapulmonary Deflation on Air Trapping in Patients With COPD

Respiratory Care April 2023, 68 (4) 478-487; DOI:


Sands, D.; Walicka-Serzysko, K.; Milczewska, J.; Postek, M.; Jeneralska, N.; Cichocka, A.; Siedlecka, E.; Borawska-Kowalczyk, U.; Morin, L. Efficacy of the Simeox® Airway Clearance Technology in the Homecare Treatment of Children with Clinically Stable Cystic Fibrosis: A Randomized Controlled Trial.

Children 2023, 10, 204.


Shah NM, Fresnel E, Kerfourn A, Morin L, Murphy PB, Patout M. A bench study to investigate the safety and performance of Simeox for secretion clearance

European Respiratory Journal 2022 60: 3300; DOI: 10.1183/13993003.congress-2022.3300


Schmidt H, Toth M, Kappler‐Schorn C, Siebeneich U, Bode SFN, Fabricius D. Short‐term effects of a novel bronchial drainage device: a pilot cohort study in subjects with cystic fibrosis.

Health Sci Rep 2022;5:e812.


Haltenberger, D. und T. Becher: Simeox zu Hause – Patient*innenbefragung zur häuslichen Simeox-Anwendung bei Mukovsizidose/Cystischer Fibrose

Simeox Clincial Notebook 5, 9/2021


K. Walicka-Serzysko, M. Postek, N. Jeneralska, A. Cichocka, J. Milczewska, D. Sands. Addition of a new airway clearance device to chest physiotherapy in children with pulmonary exacerbation of cystic fibrosis.

J Mother Child 2021 Jan 26;24(3):16-24.


Laurent Morin, Damien Marino, Adrien Mithalal. Physiological effects of Simeox Airway Clearance Device in healthy adults

European Respiratory Journal 2020 56: 1274; DOI: 10.1183/13993003.congress-2020.1274


Giovannetti.P, Morin L, Gaubert MR. Safety and Efficacy of an Innovative Airway Clearance Device Versus Manual Chest Physiotherapy Techniques For Airway Secretion Clearance: a Feasibility Study.

European Journal of Respiratory Medicine. 2020; 1(2): 132 - 137

Ivan Solovic, Alena Bodnarova, Laurent Morin. Feasibility and benefits of an innovative airway clearance device in COPD patients hospitalized for acute exacerbation.

European Respiratory Journal 2020 56: 952; DOI: 10.1183/13993003.congress-2020.952


Vitezslav Kolek, Petr Jakubec, Jana Doleželová, Laurent Morin, Jiří Kufa. Feasibility and safety evaluation of Simeox airway clearance technique (ACT) in patients with bronchiectasis.

European Respiratory Journal 2019 54: PA601; DOI: 10.1183/13993003.congress-2019.PA601 (ERS 2019 Poster)


P. Sliwinski, D. Klatka, A. Gladzka, L. Morin, K. Iwan, Benefits of Simeox airway clearance technology in non-CF patients with bronchiectasis

American Journal of Respiratory and Critical Care Medicine 2019;


F. Mihaltan, L. Morin, C. Borcea, A. Costantin, V.-C. Cosei. Evaluation of an Innovative Airway Clearance Technology in Comparison to Manual Chest Physiotherapy in Acute Exacerbation of Chronic Obstructive Pulmonary Disease (COPD).

American Journal of Respiratory and Critical Care Medicine 2019;


Florin Mihaltan, Laurent Morin, Corina Borcea, Ancuta Costantin, Alexandru Pahontu, Lucia Marinescu, Valentin-Caius Cosei. Late Breaking Abstract - Effects of a new Airway Clearance Technology versus manual physiotherapy in COPD

European Respiratory Journal 2018 52: PA4047; DOI: 10.1183/13993003.congress-2018.PA4047 (ERS 2018 Poster)


Katarzyna Iwan, Dorota Klatka, Agata Gladzka, Laurent Morin, Pawel Sliwinski. Late Breaking Abstract - Benefits of a low-frequency airway clearance technology in non-CF patients with bronchiectasis.

European Respiratory Journal 2018 52: PA805; DOI: 10.1183/13993003.congress-2018.PA805 (ERS 2018 Poster)


Clinical Documentation

Main Clinical Trials

Symposiums / Communications

Committee Advisors